Esthe Pro Labo – Exsome Premium Supplement

Premium Japanese dietary supplement with 400 million plant exosomes. Unique Eternal Young complex / Cistanche, Centella asiatica, pomegranate, ceramides. Anti-aging, collagen support, cellular vitality, and telomere protection.

Every day your cells communicate. They send tiny membrane vesicles — exosomes — that carry signaling molecules, bioactive substances, and instructions for regeneration. This natural communication system determines how quickly the skin renews itself, how effectively the body repairs damaged tissues, and how long cells maintain their vitality.

Exsome Premium Supplement from Esthe Pro Labo contains 400 million plant exosomes in each daily dose, enclosed in the unique Eternal Young complex blend.

The Eternal Young complex is not a random mixture of extracts. It is a targeted formulation that combines ingredients selected based on their scientifically documented effects on cellular vitality, collagen protection, and the deceleration of aging processes. This combination was used for the first time in Japan specifically in Exsome Premium Supplement. Each ingredient plays its role. Together, they create a synergistic effect that transcends the sum of individual components.

Exosomes are among the most closely monitored topics in modern cell biology. They are nanoscopic membrane vesicles (30–150 nm in diameter) that cells naturally secrete and that serve as "couriers" for intercellular communication. They transport microRNAs, proteins, lipids, and other bioactive molecules, thereby directly influencing the behavior of target cells.

In the context of skin and aging, their role is crucial. Research shows that exosomes are involved in regulating inflammatory processes, promoting fibroblast proliferation (cells that produce collagen and elastin), stimulating angiogenesis (the formation of new blood vessels for better tissue nourishment), and helping to maintain the homeostasis of the extracellular matrix — precisely the "network" that gives skin firmness and elasticity.

Plant exosomes (plant-derived exosome-like nanoparticles) represent a new generation of bioactive carriers. Studies published in scientific journals confirm that exosomes isolated from plant sources retain their ability to interact with human cells and deliver targeted bioactive substances with high efficacy.

In practice: 400 million exosomes in each sachet of Exsome Premium Supplement mean a massive dose of these natural "couriers" that deliver regenerative signals directly where your body needs them.

Telomere protection is not about one substance, but about a layered strategy. In the context of Exsome Premium Supplement, it looks like this: Cistanche activates telomerase (lengthening), polyphenols from pomegranate and Centella reduce oxidative stress (slowing shortening), anti-inflammatory substances suppress inflammaging (preventing accelerated loss), and urolithin A cleans mitochondria (removing the source of damage).

Four mechanisms, one goal — to keep telomeres functional for as long as possible!

Why "inside out" works better than you think
Serums, creams, and masks work on the surface. They target the stratum corneum, a thin barrier that makes up only 10–15 microns of the skin's total thickness. But true regeneration—collagen formation, elastin renewal, cell division—occurs in the deeper layers of the dermis, where topical cosmetics cannot reach.
A dietary supplement like Exsome Premium Supplement works in the opposite direction. Active ingredients are absorbed in the digestive tract, enter the bloodstream, and reach fibroblasts and keratinocytes via the blood—precisely the path the body naturally uses to supply the skin with nutrients.
Best results? A combination of both. Quality topical care + targeted supplementation from within. Exsome Premium Supplement is designed to complement your existing beauty routine with what no cream can achieve: cellular support from within.

Who is Exsome Premium Supplement for?
For women and men who perceive beauty as a manifestation of inner health. For those who want more than just to cover up—they want to truly support. For anyone looking for a premium, scientifically-backed approach to anti-aging care without synthetic additives and compromises.
One sachet a day. A ritual that takes a few seconds but works for you 24 hours a day.

Cistanche deserticola, the "desert ginseng" and guardian of your telomeres
Cistanche deserticola is an adaptogenic herb that grows in the extreme conditions of Central Asian deserts. For centuries, it has been prized in traditional Chinese medicine as an "elixir of longevity," and modern science confirms its benefits.
Research shows that the bioactive glycosides contained in Cistanche (especially echinacoside and acteoside) have a significant impact on cellular vitality. Laboratory studies have demonstrated their ability to activate telomerase, an enzyme that maintains the length of telomeres, the protective "caps" at the ends of chromosomes. Telomeres naturally shorten with each cell division, and their length is considered one of the main biomarkers of biological aging.
In addition to protecting telomeres, Cistanche supports the immune system, increases the body's antioxidant capacity, and shows neuroprotective effects in preclinical studies. It is an ingredient that targets the mechanisms of aging, not just its symptoms.

Centella asiatica, a collagen architect with a thousand-year history
Gotu kola (Centella asiatica) is among the most studied plants in dermatology. Its key triterpene saponins—asiaticoside and madecassoside—are documented in dozens of clinical and preclinical studies.
What can Centella demonstrably do? It stimulates the synthesis of type I and III collagen in fibroblasts—precisely those proteins that give skin firmness and elasticity. It improves microcirculation in the skin, meaning better oxygen and nutrient supply to cells. It supports healing and tissue remodeling. And thanks to its anti-inflammatory properties, it soothes the skin from within, helping to regulate chronic subclinical inflammation (known as "inflammaging"), which is one of the main accelerators of premature aging.
In the context of Exsome Premium Supplement, Centella does not act in isolation; its effects on the collagen matrix are synergistically enhanced by the antioxidant protection of pomegranate and vitamin C from citrus fruits, which is an essential cofactor for collagen synthesis.

Pomegranate, an antioxidant shield for your skin
Pomegranate (Punica granatum) is not just a superfood; it is one of the most powerful natural antioxidants known to science. The key compound is ellagic acid and its metabolite urolithin A, which is formed by the action of gut microflora.
Why is urolithin A so interesting? Because in preclinical studies, it has shown the ability to stimulate mitophagy—the selective "cleanup" of damaged mitochondria. Functional mitochondria mean more efficient cellular energy metabolism and thus better skin regeneration capacity.
Furthermore, pomegranate polyphenols protect collagen and elastin fibers from degradation by matrix metalloproteinases (MMPs)—enzymes whose activity increases due to UV radiation, stress, and chronic inflammation. Less collagen degradation means the skin retains firmness, elasticity, and an even tone for longer.

Citrus fruits, natural vitamin C where collagen needs it
Vitamin C (ascorbic acid) is an essential cofactor for the enzymes prolyl hydroxylase and lysyl hydroxylase, which stabilize the triple-helical structure of collagen. Without enough vitamin C, the body cannot synthesize functional collagen—and no serum in the world can save that.
Citrus extracts in Exsome Premium Supplement provide vitamin C in its natural form, along with bioflavonoids (hesperidin, naringin) that increase its bioavailability and act as antioxidants themselves. Additionally, they support skin brightening by inhibiting tyrosinase, the enzyme responsible for melanin production.

Ceramides from pineapple, barrier protection from within
Ceramides make up approximately 50% of the lipids in the intercellular space of the stratum corneum. They are literally the "mortar" that holds skin cells together and prevents transepidermal water loss (TEWL). When ceramides decrease due to age, stress, or aggressive cosmetics, the skin dries out, loses elasticity, and becomes more sensitive.
Oral supplementation with plant-derived ceramides (phytosphingosine ceramides) has been linked in clinical studies to improved skin hydration and strengthening of the skin barrier. Ceramides from pineapple in Exsome Premium Supplement replenish what the skin naturally loses and support its resilience from within.

Red-flowered Raglist (Salvia miltiorrhiza) has been used for centuries in traditional Eastern medicine for its effects on microcirculation and vascular health. It contains tanshinones and salvianolic acids—substances with proven antioxidant and anti-inflammatory properties. In the context of anti-aging care from within, it contributes to better blood flow in the skin, and thus to more efficient nutrient and oxygen supply to the skin.

Take 1 sachet per day (2 tablets), ideally after a meal. The recommended duration of treatment is at least 30 days for visible effects on the skin, vitality and overall regeneration.

260 mg x 2 tablets in one bag
30 bags

Active substance content per daily dose (1 sachet)
"Eternal Young" complex – plant exosomes
400 million exosomes in extract form (113 mg)

Extracts:
Small-leaf beautyberry – 28 mg
Gotu Kola – 28 mg
Pomegranate – 28 mg
Citrus fruits – 28 mg
Red-flowered ragwort extract – 53 mg
Ceramides from pineapple (4%) – 2 mg

Total weight: 7.8 g

Ingredients
Plant exosomes, "Eternal Young" complex of plant extracts, dextrin and starch (fillers), red-flowered ragwort extract, saturated oil, silicon dioxide (anti-caking agent), ceramides.

Warning
Do not exceed the recommended daily dose. Not a substitute for a varied diet.
Storage: up to 25°C, away from direct sunlight. Keep out of reach of children.

Food supplement. Not a substitute for a varied and balanced diet and a healthy lifestyle. Do not exceed the recommended daily dose. Keep out of reach of children. Scientific references in the text refer to published laboratory and preclinical studies; individual results may vary.