Autophagy
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The body has its own renewal system. Autophagy is a natural cellular process where cells break down and recycle their damaged components — allowing them to regenerate, function more efficiently and for longer.
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What is Autophagy?
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Autophagy is one of the most important biological mechanisms associated with cellular renewal, damage prevention, and healthy aging. The world owes a major breakthrough in this field to Japanese scientist Yoshinori Ohsumi, who elucidated the basic mechanisms of autophagy and was awarded the Nobel Prize in Physiology or Medicine in 2016 for this contribution.
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His work was continued by Professor Tamotsu Yoshimori, who significantly expanded research into autophagy in mammals. He became famous, among other things, for the discovery of LC3, a key marker of autophagosomes, and later for his research into the protein Rubicon, which is involved in suppressing autophagy during aging and metabolic stress. Together, their work laid the scientific foundation for today's research into longevity, cellular regeneration, immunity, skin aging, and preventive medicine. "Professor Tamotsu Yoshimori, a leading Japanese scientist in the field of autophagy, was professionally involved in the development of the ingredient concept for the HAKKO BLACK HERBZYME product from Esthe Pro Labo.
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Nobel Prize for a Discovery That Changes the View of Aging
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In 2016, Japanese biologist Yoshinori Ohsumi received the Nobel Prize in Physiology or Medicine for his elucidation of the mechanisms of autophagy. His research was the first to scientifically describe how cells digest and recycle their own damaged parts—a process that occurs in each of us but whose depth had long been unknown. Ohsumi's discovery opened a new chapter in understanding aging, immunity, and cellular health.
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What's happening inside the cell
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The word autophagy comes from Greek and literally means "self-eating." A cell marks its worn-out or damaged components, encloses them in vesicles, and breaks them down into basic building blocks which it then reuses. This is a natural cleansing mechanism – without it, cellular waste would accumulate in cells, leading to accelerated aging, inflammation, and reduced vitality.
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Why Autophagy Declines with Age
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After the age of thirty, the natural intensity of autophagy gradually declines. Cells become less efficient at cleansing themselves, accumulate damaged proteins, and lose their ability to regenerate effectively. This manifests in energy levels, skin quality, immunity, and an overall sense of vitality. This is precisely why supporting autophagy is one of the most discussed topics in modern preventive medicine and anti-aging science.
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How to support autophagy
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Autophagy is naturally activated by intermittent fasting, exercise, and specific bioactive substances. The fermented enzymatic beverages from the Herbzyme byFEMME line combine long-term Japanese fermentation with functional ingredients—black garlic, black ginger, and maca—which are scientifically studied in the context of supporting cellular renewal. Herbzyme Hakko Black was tested in the tfLC3 cellular assay, where the EGFP/mRFP ratio decreased after its addition—a standard indicator of higher autophagic flux.
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Autophagy is not a trend. It's a mechanism you have in every cell of your body—one that can be consciously supported. Not magically, but physiologically.
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Pro Labo Concept
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